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April 2020, Volume 23,No12 Abstracts(B)

Research Status of Transitional Care for Cancer Survivors LIU Huiyu1,2,ZHAO Qiuli1,2*,FAN Shuoning1,2
1.School of Nursing,Harbin Medical University,Harbin 150086,China
2.Department of Oncology,the 2nd Affiliated Hospital of Harbin Medical University,Harbin 150086,China
*Corresponding author:ZHAO Qiuli,Professor,Master supervisor;E-mail:zhaoqiuli1957@163.com
【Abstract】 With the development of medical technology,the survival period of cancer patients has been significantly prolonged,and the number of cancer survivors has gradually increased,which makes the need for transitional care has become increasingly prominent.However,the transitional care started late in China,and there is still a certain gap compared with the mature model abroad.This paper summarizes the contents,methods,effect evaluation and progress of the transitional care for cancer survivors,and puts forward that transitional care measures such as disease monitoring,psychological support and self-nursing skills guidance besides lifestyle intervention can also be taken.It is pointed out that in addition to the evaluation indexes of quality of life and economic benefits,functional indexes,clinical indicators,negative emotion indicators and nursing quality indicators could also be selected for comprehensive evaluation,which could provide a reference and basis for the construction of transitional care model suitable for China's national conditions.
【Key words】 Neoplasms;Cancer;Survivors;Transitional care;Review
 
Research Progress in the Treatment of Pain from Metastatic Bone Cancer WANG Xiao1,CHEN Li2,LIU Guangjie3,ZHANG Changquan4,WU Haina1,LI Dehui1,FAN Huanfang1*
1.Department of Oncology Division 2,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China
2.Department of General Practice,Hebei Tumor Hospital,Shijiazhuang 050011,China
3.Department of Thoracic Surgery,Hebei Tumor Hospital,Shijiazhuang 050011,China
4.Department of Orthopedics,Weixian Hospital of Traditional Chinese Medicine,Weixian 054700,China
*Corresponding author:FAN Huanfang,Chief physician,Professor;E-mail:812107816@qq.com
【Abstract】 Bone metastatic cancer is a common complication of tumor patients,and its incidence accounts for about 15%-20% of systemic metastatic cancer following the incidence of lung and liver metastatic cancer.Malignant tumors prone to bone metastasis include lung cancer,breast cancer,prostate cancer,etc.Pain is the most common clinical symptom of bone metastasis,and its early symptoms are insidious.As the disease progresses,the symptoms become worsen,and the acute pain is in the late stage,which poses a serious threat to the quality of life of cancer patients.Therefore,this paper systematically introduces the current situation of the treatment of pain from bone metastatic cancer through western and traditional Chinese medicine by reviewing domestic and foreign literatures,so as to provide suggestions and references for the clinical treatment of pain from bone metastatic cancer.
【Key words】 Bone neoplasms;Bone metastasis cancer;Pain;Therapy;Review
 
Research Progress on Interaction between Tumor Microenvironment and Regulation of the Stemness of Colorectal Cancer MU Lanlan,GAO Lu,ZHU Rong,ZHAO Kui*
Department of Gastroenterology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China
*Corresponding author:ZHAO Kui,Professor,Chief physician,Master supervisor;E-mail:kuizhao95868@msn.com
【Abstract】 Colorectal cancer(CRC)is one of the most common malignant tumors in the digestive system.The theory of tumor stem cells(CSCs)brings new hope for the prevention and treatment of CRC.According to the theory,CSCs are the root of recurrence and metastasis of CRC.Only by eliminating CSCs can we really eliminate tumor cells.However,it was found that the dryness of colorectal cancer stem cells(CCSC)is a dynamic process regulated by tumor microenvironment(TME).This paper introduces how TME participates in the regulation of CCSC dryness,briefly describes that the components of TME participate in the regulation of tumor dryness and the formation of immune tolerance by secreting various regulatory protein molecules,and describes how the signal pathways of Wnt,Notch,BMP and Hedgehog in the intestinal crypt cooperate and antagonize each other to maintain the proliferation and differentiation of the intestinal crypt stem cells.Finally,we proposed that TME plays an important role in the maintenance of CCSC dryness and the dedifferentiation of tumor cells.The maintenance of CCSC dryness is strongly dependent on external signals from its microenvironment.Only targeted treatment for CCSC and TME can eliminate CCSC and prevent differentiated tumor cells from dedifferentiating to restore their dryness,which is the key to targeted treatment for CRC.
【Key words】 Colorectal neoplasms;Colorectal cancer;Neoplastic stem cells;Tumor microenvironment;Colorectal cancer stem cell

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