March 2018, Volume 21, No.9 Abstracts（A）
1.Department of Geriatrics，Peking University First Hospital，Beijing 100034，China
2.Department of Cardiology，Peking University First Hospital，Beijing 100034，China
*Corresponding author：ZHOU Jing，Chief physician；E-mail：email@example.com
【Abstract】 Arrhythmia is one of the most common type of cardiovascular diseases among community groups with high morbidity and mortality. As the general term for a group of heterogeneous diseases，different arrhythmias have different impacts on patients. Therefore，potentially high-risk patients should not be missed，while the treatment of low-risk patients should not be excessive. This article introduces treatment principles of common arrhythmias in communities in order to provide the reference for doctors at the grass-roots level to quickly identify and handle common arrhythmias in communities.
【Key words】 Arrhythmias，cardiac；Community health service centers；Diagnosis，differential；Therapy
Recent Advances in the Role of Microbiota-gut-brain Axis in the Pathogenesis of Parkinson's Disease HE Yi，YU Gang*，ZHENG Peng，WANG Hao-tian
Department of Neurology，the First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China
*Corresponding author：YU Gang，Associate professor，Chief physician；E-mail：firstname.lastname@example.org
【Abstract】 Parkinson's disease（PD） is a common neurodegenerative disease. The major pathological changes of PD are abnormal aggregation of α-synuclein in the substantia nigra. However，in recent years，more and more studies have found that the enteric nervous system also has α-synuclein abnormal aggregation except the brain. The microbiota-gut-brain axis is the bidirectional communication system between the central nervous system and the gastrointestinal tract and involves neural pathways，immune and endocrine mechanisms. The enteric nervous system may spread α-synuclein through the vagus nerve to the central nervous system，so many scholars believe that PD may initially originate from the gastric-intestinal tract. In this paper，a brief review about the studies of the role of microbiota-gut-brain axis in the pathogenesis of PD in recent years will help us to explain the potential pathogenesis and some clinical features of PD. It may provide a new direction for the diagnosis and treatment of PD.
【Key words】 Parkinson disease；Enteric nervous system；Neuroimmunomodulation；Microbiota-gut-brain axis
Mechanism of Ventricular-arterial Coupling and Its Influencing Factors ZHOU Xiao-yang，XU Zhao-jun*
Department of Intensive Care Medicine，Ningbo No.2 Hospital，Ningbo 315000，China
*Corresponding author：XU Zhao-jun，Chief physician；E-mail：email@example.com
【Abstract】 Ventricular-arterial coupling refers to a matching relationship between cardiac function and peripheral vessels. The heart still can provide adequate blood for peripheral organs even in pathological conditions by adjusting the matching arterial properties. At present，the researches on ventricular-arterial coupling mainly focus on the field of cardiac diseases，pulmonary diseases and circulatory shock. This paper summarizes the research progress on the mechanism of ventricular-arterial coupling and its influencing factors in above fields.
【Key words】 Electrophysiologic techniques，Cardiac；Heart ventricles；Hypertension；Shock，septic
Recent Advances in MicroRNAs in Heart Failure XU Man-man1，ZHANG Jiu-liang1，FAN Shu-ying2*
1.Department of Integrative Cardiology，China-Japan Friendship Hospital，Beijing 100029，China
2.Department of Cardiology，China-Japan Friendship Hospital，Beijing 100029，China
*Corresponding author：FAN Shu-ying，Associate chief physician；E-mail：firstname.lastname@example.org
【Abstract】 MicroRNAs（miRNAs） belong to a class of evolutionarily conserved non-coding endogenous small RNAs，which can post-transcriptionally regulate gene expression via specific binding to target gene 3' untranslated region，and participate in multiple physiological and pathological processes in the body. Recently，miRNAs have been found to play an important role in myocardial fibrosis，cardiomyocyte hypertrophy as well as apoptosis. Besides，miRNAs are involved in the occurrence and development of heart failure，and can be used as a kind of new biomarkers in the diagnosis，treatment and prognosis for heart failure，thus are expected to be a new potential therapeutic target. Consequently，the recent advances in miRNAs related to heart failure was reviewed in this paper，providing a novel therapeutic method for cardiovascular disease.
【Key words】 Heart failure；MicroRNAs；Biomarkers
Risk Factors Associated with Brain Atrophy in Elderly Patients GAO Zhi-yu1，DIAO Jia-gui2，YANG Tuan-feng1，GAO Xu-guang3*
1. Department of Neurology，Peking University International Hospital，Beijing 102206，China
2. Department of Neurology，Zichuan District Hospital，Zibo 255100，China
3. Department of Neurology，Peking University People's Hospital，Beijing 102206，China
*Corresponding author：GAO Xu-guang，Professor；E-mail：email@example.com
【Abstracts】 Objective To explore the related influencing factors associated with brain atrophy（BA） in elderly patients. Methods The enrolled participants were patients aged≥60 years old who received inpatient treatment in Department of Neurology，Zichuan District Hospital from October 2013 to October 2014. All the patients measured the blood glucose（Glu），triglyceride（TG），total cholesterol（TC），high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C），and based on the measurement results received hypoglycemic and lipid-lowering therapies，as well as underwent brain MRI. The prevalence of BA was assessed in accordance with the brain MRI results. Those with BA and those without were assigned to BA group，and non-BA group，respectively. Baseline characteristics such as gender，age，diagnosis as well as laboratory findings were compared between the two groups. Ordinal logistic regression analysis was carried out to explore the factors associated with BA scores. Results Two groups demonstrated significant differences in the baseline characteristics（P<0.05）（except TG and HDL-C）. Ordinal Logistic regression analysis showed that sex〔OR=2.776，95%CI（1.754，4.393），P<0.05〕，age〔OR=1.142，95%CI（1.108，1.176），P<0.05〕，diagnosis 〔OR=3.717，95%CI（1.570，8.811），P<0.05〕，and levels of LDL-C〔OR=0.510，95%CI（0.304，0.856），P<0.05〕were the associated factors of BA scores in elderly patients. Conclusion Male，older age，history of ischemic stroke，and decreased LDL-C level may be the independent risk factors for high BA score.
【Key words】 Aged；Brain diseases；Brain atrophy；Blood glucose；Dyslipidemias；Lipoproteins，LDL；Root cause analysis
Effect of Individual Computer Magnanimous Therapy on Brain Wave Test Results and Scores of HADS in Patients with Lung Cancer YAN An-ni1，HUANG Xue-wei1*，WU Lan-lan2
1.Department of Psychiatry，the First Affiliated Hospital of Guangdong Pharmaceutical University，Guangzhou 510080，China
2.Guangzhou Huiai Hospital，Guangzhou 510170，China
*Corresponding author：HUANG Xue-wei，Professor，Chief physician；E-mail：firstname.lastname@example.org
【Abstract】 Objective To explore the influence of Individual Computer Magnanimous Therapy（ICMT） on brain wave test results and Hospital Anxiety and Depression Scale（HADS） among lung cancer patients. Methods According to the enrollment criteria of this study，we recruited 82 cases of lung cancer who received treatment in the First Affiliated Hospital of Guangdong Pharmaceutical University from January 2015 to March 2017 and divided them into the experimental group and control group with 41 cases in each based on the matched case-control study design. Both groups received conventional antineoplaston therapy，the experimental group additionally received ICMT. Brain wave values（α，β，θ and SMR wave），scores of HADS and its subscales were compared before treatment and 2 weeks after treatment between the two groups. Correlations of brain wave values of the experimental group（α，β，θ and SMR wave） with HADS scores were analyzed. Results After receiving treatment，compared with the control group，the experimental group demonstrated much higher