February 2018, Volume 21, No.6 Abstracts（A）
Interpretation of 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis GAO Ying，ZHAO Dong-bao*
Department of Rheumatology and Immunology，Changhai Hospital，Shanghai 200433，China
*Corresponding author：ZHAO Dong-bao，Professor，Chief physician；E-mail：firstname.lastname@example.org
【Abstract】 Glucocorticoid-induced osteoporosis（GIOP） ranks first in secondary osteoporosis. The effect of glucocorticoids（GCs） on bone mass persists and there is no safety threshold. Therefore，prevention and treatment of GCs is always appropriate at any time. With more evidence and experience gained about clinically important features of GIOP，its fracture risk assessment and better decisions during intervention period and follow-up，the American College of Rheumatology again launched the new GIOP guidelines in 2017. This article summarized the fracture risk stratification，timing of assessment and reassessment，initial and follow-up treatment strategies for general/special populations in order to update notion of clinicians treating GIOP.
【Key words】 Osteoporosis；Glucocorticoids；Fractures，bone；Guidebooks
Historical Development of In Vitro Diagnostics Technology in China XING Jing-hua
Institute of Medical Humanities，Peking University，Beijing 100191，China
【Abstract】 Since the founding of new China，the development of in vitro diagnostics technology in China has been more than 60 years from the original manual method to the whole process of standardization，intelligent，automated management with different characteristics in different times. The discipline concept of in vitro diagnostics changes from medical examination to laboratory medicine providing clinically significant pathological and physiological information，which is an important part of the diagnosis and treatment of patients.
【Key words】 Diagnostic techniques and procedures；China；In vitro diagnostic
Recent Developments in the Association of Anxiety and Depression with Blood Pressure Variability WANG Shu-juan，ZHANG Qing-tan*
Department of Geriatric Medicine，Binzhou Medical University Hospital，Binzhou 256600，China
*Corresponding author：ZHANG Qing-tan，Professor，Chief physician；E-mail：email@example.com
【Abstract】 With the rapid development of society，the prevalence and incidence of anxiety and depression are increasing. Most studies have confirmed that anxiety and depression are closely related to hypertension and other cardiovascular diseases. As a parameter recently used for monitoring the changes in blood pressure，blood pressure variability（BPV） can well reflect the blood pressure status over a 24-hour period，circadian variations of blood pressure，circadian rhythm of blood pressure，hence it is contribute to the evaluation of the curative effect of anti-hypertension，and to the diagnosis and treatment of hypertension. We reviewed the recent studies concerning the impact and mechanism of action of anxiety and depression on BPV，and proposed an effective and safe anti-hypertension regimen.
【Key words】 Anxiety；Depression；Blood pressure variability
Association Analysis on Clinical Objective Indicators and Patient-reported Outcomes in Patients with Stroke based on the SF-36 Scale XU Qing-an1，CHANG Lyu-hua2，WAN Chong-hua1*，SUN Feng-qin2，XU Chuan-zhi3，LIU Zhou4
1.Research Center on Quality of Life and Applied Psychology，School of Humanities and Management，Guangdong Medical University，Dongguan 523808，China
2.Department of Neurology，First Affiliated Hospital of Kunming Medical University，Kunming 650032，China
3.School of Public Health，Kunming Medical University，Kunming 650500，China
4.Institute of Neurology，Guangdong Medical University，Zhanjiang 524001，China
*Corresponding author：WAN Chong-hua，Professor；E-mail：firstname.lastname@example.org
【Abstract】 Objective To explore the relationship between patient-reported outcomes（PRO） and clinical objective indicators in stroke patients. Methods One hundred inpatients diagnosed with stroke and received treatment in Department of Neurology，First Affiliated Hospital of Kunming Medical University from May 2010 to March 2011 were selected as the subjects，and SF-36 Scale was used to measure their PRO. The clinical objective indicators measured on the second day after admission were collected from the medical records，including albumin，globulin，urea，fasting blood glucose，blood potassium，platelet count，activated partial thromboplastin time，and degree of education. The correlation between PRO and clinical objective indicators was analyzed by simple correlation and canonical correlation. Results Simple correlation analysis showed that globulin was negatively correlated with bodily pain（BP），vitality（VT）（P<0.05） ；urea was negatively correlated with physical functioning（PF）（P<0.05） ；fasting blood glucose was negatively correlated with general health perceptions（GH）（P<0.05） ；blood potassium was negatively correlated with PF（P<0.05） ；platelet count was negatively correlated with PF（P<0.05） ；educational level was positively correlated with PF，BP，VT，and emotional role functioning（RE）（P<0.05） . Canonical correlation analysis showed that canonical variables（μ1，ν1），（μ2，ν2） existed correlation（r=0.536 0，r=0.325 6，P<0.05） . Canonical variable coefficient of globulin and μ1 was -0.832 2，canonical variable coefficient of activated partial thromboplastin time and μ1was 0.358 5；canonical variable coefficient of platelet count and μ2 was 0.581 6，canonical variable coefficient of educational level and μ2 was 0.672 0；canonical variable coefficient of VT and ν1 was 1.061 7，canonical variable coefficient of mental health（MH） and ν1 was -0.761 8，canonical variable coefficient of PF and ν2 was -0.950 1，canonical variable coefficient of GH and ν2 was 0.443 8. Globulin was highly negatively correlated with μ1（r=-0.835 0，P<0.05）. PF was highly negatively correlated with ν2（r=-0.738 6，P<0.05） . VT was highly positively correlated with ν1（r=0.727 2，P<0.05） . Conclusion Clinical objective indicators correlate with PROs in stroke patients. Therefore，taking interventions based on the values of these indicators is of some significance in improving the PROs of these patients.
【Key words】 Stroke；Patient-reported outcomes；Clinical objective indicators；Correlation analysis
Functional Connectivity of Default-Mode Network Related Brain Regions in Female Patients with Depression：a Resting-State Functional Magnetic Resonance Imaging Study LI Jing1，2，ZHAO Bing1，3，WANG Xi-lin1*，LIAO Jin-min1，LIU Ying4，ZHANG Han5，CHEN Man-man6
1.Peking University Sixth Hospital / Institute of Mental Health（Peking University） / Key Laboratory of Mental Health，Ministry of Health（Peking University），Beijing 100191，China
2.Psychiatric Department，Beijing Huilongguan Hospital，Beijing 100096，China
3.Neurology Department，Changzhi People's Hospital，Changzhi 046000，China
4.Radiology Department，Peking University Third Hospital，Beijing 100191，China
5.Psychiatric Department，Beijing Huaxin Hospital，Beijing 100016，China
6.Qingdao Mental Health Center，Qingdao 266000，China
*Corresponding author：WANG Xi-lin，Chief physician；E-mail：email@example.com
【Abstract】 Objective To explore the