February 2014, Volume 17, No.6 Abstracts
Research Progress on Resilience of the Breast Cancer Patients
ZHANG Ting,LI Hui-ping,YANG Ya-juan,et al.School of Nursing,Anhui Medical University,Hefei 230601,China
【Abstract】 Resilience has become a hot spot in the field of positive psychology in recent years.Many studies have shown that resilience played an important role in coping with trauma or stressful events.This paper reviewed the concept,assessment tools,related factors and intervention methods of resilience in women with breast cancer in order to provide new clues to the development of clinical psychological care for breast cancer patients.
【Key words】 Resilience；Breast neoplasms；Review
Research Progress on Blood Biomarkers to Forecast Kidney Injury in Children with Henoch-Schonlein Purpura
HUANG Sai-ping，ZHOU Tai-guang.Department of Pediatric,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China
【Abstract】 Henoch-Schonlein purpura(HSP) is a common disease in children,which could develop into Henoch-Schonlein purpuritic nephritis,or even severe renal injury and resulted in renal failure and can seriously affect children′s life quality.Currently,the most reliable method to diagnose HSP kidney damage is renal biopsy,which is with high risk and piercing damage,thus not well accepted by children and their parents.Recently,with the progress of the research on proteomics and gene molecular biology,more attention is paid to sensitive blood biomarkers which could predict severe kidney damage in children with HSP.This article reviews the interrelated research progress.
【Key words】 Purpura，Schonlein-Henoch；Henoch-Schonlein purpuritic nephritis；Vascular cell adhesion molecule-1；Cysteine proteinase inhibitors；Matrix metalloproteinases
Prevalence and Factors Associated with White Matter Lesions of the Cerebellum and the Pons among Patients with Acute Cerebral Infarct
GAO Tian-li，LIU Chun-jie.Department of Neurology，Beijing Anzhen Hospital Affiliated to Capital Medical University，Beijing 100029，China
【Abstract】 Objective To investigate prevalence and risk factors associated with white matter lesions(WML) of the cerebellum and the pons among patients with acute cerebral infarct.Methods A total of 206 acute cerebral infarct patients who were admitted to our hospital from October 2011 to October 2012，were selected as study subjects，MRI findings were analyzed retrospectively to identify the presence of WML of the cerebellum and the pons.Multiple Logistic regression analysis was used to identify risk factors associated with WML of the cerebellum and the pons.Results Among 206 patients，65(31.6%) patients had WML of the cerebellum and the pons，42(64.6%) patients had bilateral lesions，39(60.0%) patients also had supratentorial WML.Age，prevalences of hypertension，supratentorial infracortical WML，multiple lacunar infarction among patients with WML of the cerebellum and the pons were significantly higher than those among patients without WML of the cerebellum and the pons（P＜0.05）.According to results of Logistic regression analysis，supratentorial subcortical WML〔OR=2.3，95%CI（1.4，7.5)〕 and multiple lacunar infarction〔OR=2.1，95%CI（1.9，5.6)〕 were independently related to WML of the cerebellum and the pons.Conclusion WML of the cerebellum and the pons exist in nearly a third of patients with acute cerebral infarct，supratentorial subcortical WML and multiple lacunar infarction were risk factors for WML of the cerebellum and the pons.
【Key words】 Stroke；White matter lesions；Cerebral small vessel disease；Risk factors
Association between the Urinary Microalbumin/Creatinine Ratio and Lipoprotein(a) among Elderly Type 2 Diabetic Patients
YU Ping，ZHU Min.Nanxiang Town Community Health Service Center of Jiading District，Shanghai 201802，China
【Abstract】 Objective To analyze the relationship between the urinary microalbumin/creatinine ratio(UACR) and lipoprotein(a)〔Lp（a）〕in elderly type 2 diabetic(T2DM) patients.Methods A total of 106 elderly patients with T2DM and 30 patients with other diseases who were treated in our hospital form January 2011 to October 2012，were selected as study participants.T2DM patients were divided into diabetic nephropathy group(UACR≥30 mg/g，50 cases) and non-diabetic nephropathy group(UACR＜30 mg/g，56 cases)，while cases with other diseases were selected as the non-diabetic control group.The biochemical indexes and urinary microalbumin were detected among all cases，the correlation between indexes and UACR was analyzed by Pearson correlation analysis，risk factors for UACR among T2DM patients were analyzed by Logistic regression analysis.Results There were significant differences in levels of low density lipoprotein cholesterol(LDL-C)，apolipoprotein B(ApoB)，Lp(a)，urea，creatinine，fasting blood glucose(FBG)，glycosylated hemoglobin(HbA1c) and UACR among three groups(P＜0.05).In non-diabetic control group and non-diabetic nephropathy group，there was no correlation between Lp(a) level and UACR(r=-0.290，P=0.120；r=0.163，P=0.230).In diabetic nephropathy group，Lp(a) level was positively correlated with UACR(r=0.363，P＜0.01).Single factor Logistic regression analysis showed that the diabetes duration，diastolic blood pressure，levels of LDL-C，ApoB，Lp(a)，HbA1c and fasting C peptide(FCP) were possible risk factors for UACR(P＜0.2).The multivariate Logistic regression analysis showed that FCP level，diabetes duration and Lp(a) level were independent risk factors for UACR(P＜0.05).Conclusion In patients with diabetic nephropathy，Lp(a) level are positively correlated with UACR，and Lp(a) level is one of the independent risk factors for UACR，so Lp(a) level can indirectly reveal the kidney damage in T2DM patients.
【Key words】 Diabetes mellitus，type 2；Diabetic nephropathies；Albuminuria；Lipoprotein（a）；Urinary microalbumin/creatinine ratio
Relationship between Cerebral Small Vessel Disease and Microalbuminuria in Essential Hypertension Patients
JIANG Guang-en，SHEN Xiu-zhang,GAN Li-ping，et al.Department of Cadre Ward,Zhongshan Hospital Affiliated to Xiamen University,Xiamen 361004,China
【Abstract】 Objective To explore the relationship between cerebral small vessel disease(SVD) and microalbuminuria in essential hypertension patients.Methods A total of 100 essential hypertensive patients who were diagnosed in inpatient and outpatient department of Zhongshan Hospital Affiliated to Xiamen University from January 2008 to December 2012,were divided into SVD-positive group and SVD-negative group according to MRI.Clinical data of the two groups,such as age,sex,body mass index,systolic blood pressure,diastolic blood pressure,pulse blood pressure,fasting plasma glucose,total cholesterol,triglycerides,creatinine and microalbuminuria were recorded,and influence factors of SVD among essential hypertensive patients were analyzed by single factor analysis and multiple Logistic regression.Results There were no significant differences in sex,body mass index,diastolic blood pressure,fasting plasma glucose,total cholesterol,triglycerides and creatinine between SVD-positive group and SVD-negative group（P＞0.05）.There were significant differences in age,systolic boold pressure,pulse blood pressure and microalbuminuria between two groups（P＜0.05）.According to multiple Logistic regression analysis result,the age,systolic boold pressure and microalbuminuria were associated with the occurrence of SVD（P＜0.05）.Conclusion The age,systolic boold pressure and microalbuminuria were independent risk factors for SVD,which indicated that there was some correlation between SVD and early renal damage in essential hypertensive patients.
【Key words】 Hypertension；Cerebral small vessel disease;Microalbuminuria
Effects of Different Dosage Forms of Vitamin D on Serum PTH and T-AOC of Women at Reproductive Age
ZHENG Zhen,LI Shi-yun,LI Qin.Department of Endocrinology,Lu′an Affiliated Hospital of Anhui Medical University,Lu′an People′s Hospital,Lu′an 237000,China
【Abstract】 Objective To explore the effects of different dosage forms of vitamin D on serum PTH and T-AOC of women at reproductive age.Methods 78 healthy premenopausal women admitted to the Affiliated Hospital of Chengdu University from September to October in 2012 were randomly divided into VitD2 group(38 cases) and oral group(40 cases).The VitD2 group was given vitamin D2 injection by 400 000 U once every two weeks,while the oral group was given one calcium carbonate D3 tablet and multivitamin and minerals tablet respectively every day.Both groups were treated for eight weeks.The serum PTH and T-AOC were measured before and after the treatment.Results Before intervention,the serum PTH 〔(28.22±11.98)ng/L vs.(28.05±13.20)ng/L〕 and T-AOC 〔(22.69±5.26)U/ml vs.(23.56±5.24)U/ml〕in VitD2 group and oral group showed no statistically significant difference(P＞0.05).After intervention,the serum PTH〔(22.97±8.94)ng/L vs.(29.30±10.84)ng/L〕 was decreased and T-AOC〔(34.03±10.58)U/ml vs.(23.60±6.07)U/ml〕 was increased in VitD2 group than in oral group(P＜0.05).Conclusion Megadose of vitamin D can reduce the level of serum PTH of women at reproductive age and increase the level of T-AOC,thus improving the oxidative stress state of the body.
【Key words】 Vitamin D；Female;Parathyroid hormone；Total antioxidative capacity
Effects of Pressure Titration by Two Different Configurations on the Treatment Compliance of OSAHS Patients Undergoing Nasal CPAP
CUI Xiao-chuan，SHI Ling-zhi，HUANG Li-rong,et al.Department of Respirology，People′s Hospital of Wuxi，Wuxi 214023，China
【Abstract】 Objective To investigate the effects of two pressure titration methods by monitoring of overnight polysomnography(PSG) and overnight pulse oximetry on the treatment compliance of OSAHS patients undergoing nCPAP.Methods 66 moderate to severe OSAHS patients(AHI＞20/hour) who were willing to take pressure titration nCPAP treatment were divided into two groups with randomly single-blinded method.The 31 cases in group A was given pressure titration by PSG monitoring,while the 35 cases in group B was given pressure titration by overnight pulse oximetry monitoring.The results of pressure titration of the two groups(AHI,minimum pulse oximetry,pressure and mask air leakage) and treatment compliance of nCPAP(regular usage rate of machine,average usage hour per day and average usage days per month) were compared between the two groups.Results AHI,minimum pulse oximetry,pressure,mask air leakage,regular machine usage rate,average machine usage hour per day and average machine usage days per month showed no statistically significant difference between the two groups(P＞0.05).Conclusion Although the monitoring methods of pressure titration are different,the outcome of titration and patients′ compliance to the therapy are not affected.Since the overnight pulse oximetry is more cost-efficient and easier to be managed than PSG,it should replace the PSG in clinical application.
【Key words】 Pulmonary disease,chronic obstructive；Continuous positive airway pressure；Patient compliance
Correlation and Clinical Significance of Small Breast Epithelial Mucin and Focal Adhesion Kinase in Triple-negative Breast Cancer
ZHANG Wei,ZHANG Chen-yu,YANG Zhi-qiang,et al.Liaoning Medical University,Jinzhou 121001,China
【Abstract】 Objective To detect the expression of small breast epithelial mucin(SBEM) and focal adhesion kinase(FAK) in triple-negative breast cancer(TNBC) tissues,and to explore the correlation between the two and their clinical significances.Methods Paraffin specimens of 67 cases diagnosed as breast cancer from 2005 to 2007 in the First Affiliated Hospital of Liaoning Medical University were collected.Immunohistochemical staining was used to detect the expression of SBEM and FAK in TNBC tissues.Contingency tables independence χ2 test was used to analyze the correlation between the two,Kaplan-Meier survival analysis was used to conduct survival analysis and Cox proportional hazards model was used to conduct multivariate analysis for prognostic factors.Results The positive rate of SBEM and FAK was 52.2%(35/67) and 68.7%(46/67) respectively in TNBC.Histological grade,lymph node metastasis and Ki67 were correlated with the positive expression of SBEM and FAK in TNBC(P＜0.05),while menstrual status,age and tumor diameter were not correlated with their positive expression(P＞0.05).SBEM was correlated with FAK,with a contingency coefficient of 0.438.The disease-free survival(DFS) of the SBEM positive group was 21.4 months,and the overall survival(OS) was 28.9 months.The DFS of the SBEM negative group was 23.3 months,and the OS was 35.6 months.The difference was statistically significant(P＜0.05).The DFS and OS in the FAK positive group were 20.7 months and 25.4 months respectively,and the DFS and OS in the FAK negative group were 22.9 moths and 32.5 months respectively,showing statistically significant difference(P＜0.05).The 5-year DFS of the 67 TNBC patients was 7.5%,and the 5-year OS was 13.4%.Multivariate analysis by Cox model showed that histological grade,lymph node metastasis,Ki67,SBEM and FAK were independent prognostic factors of 5-year DFS and 5-year OS(P＜0.05).Conclusion SBEM and FAK may play an important regulatory role in the occurrence and development of breast cancer,and are the prognostic factors of TNBC adverse prognosis.The positive expression of SBEM and FAK in TNBC are correlated,the combined detection of the expression of the two may provide references for the metastasis and prognosis of TNBC.
【Key words】 Breast neoplasms；Mucins；Focal adhesion kinase；Disease-free survival
The Inhibition Role of ALDH2 Activated by Omeprazole on Apoptosis of Neuron
ZOU Hao-jun，LIN Li-li，SUN Da.Department of Pharmacology，Wuxi Higher Health Vocational Technology School，Wuxi 214028，China
【Abstract】 Objective To investigate the effects of omeprazole(OME) on injured neuron induced by oxygen glucose deprivation(OGD) and the possible mechanism.Methods A SD pregnant rats was selected，on day 15~16 of gestation，neurons isolated from newborn rat cerebral cortex were cultured in vitro for seven days，then neurons were randomly divided into control group，OGD group，and OGD+OME group(3，10，30，100，300 μg/ml OME was added in separately).Proliferation of neurons was detected by CCK-8.Injury and apoptosis of neurons were detected by Hoechst 33342 fluorescence staining and TUNEL，neurons apoptosis rate was detected by Annexin V/PI flow cytometry.To observe the effects of ALDH2 agonist(Adal1) and retardant(Cya) on injured neuron induced by OGD.Neurons of control group，OGD group and OGD+OME group（10 μg/ml OME） were collected，the activities of ALDH2 were measured.Results Proliferation of primary neurons which were cultured in vitro in OGD group was significantly lower than that in control group〔OD450：（0.370±0.027） vs.（0.959±0.062），P＜0.05〕.Apoptosis rate of primary neurons in OGD group was significantly higher than that in control group〔（33.53±1.41）% vs.（15.42±1.29）%，P＜0.05〕.Proliferation of primary neurons in OGD+OME group(10，30 μg/ ml OME) was significantly higher than that in OGD group（P＜0.05），apoptosis rate of primary neurons in OGD+OME group(10，30 μg/ ml OME) was significantly lower than that in OGD group（P＜0.05）.Apoptosis rate of primary neurons in which ALDH2 agonist(Adal1) were added was significantly lower than that in OGD group〔（16.73±0.62）%vs.（28.92±0.12）%，P＜0.05〕.Apoptosis rate of primary neurons in which retardant(Cya) were added was significantly higher than that in OGD group〔（45.22±3.23）% vs.（28.92±0.12）%，P＜0.05〕.Compared with the control group，the activities of ALDH2 in neurons among OGD group decreased by 74.01%，OME(10 μg/ml) increased the activities of ALDH2 in neurons among OGD group by 130.00%.Conclusion OME can protect injured neuron induced by OGD，which may be related to anti-apoptosis and increasing the activity of ALDH2.
【Key words】 Omeprazole；Neurons；Apoptosis；Cell proliferation；Aldehyde dehydrogenase 2
Effects of Blood Glucose Fluctuation and Calcitonin Gene-related Peptide on Kidney Diseases in Diabetic Rats
WANG Ya-jiao,SU Ke，LONG Yan，et al.Department of Endocrinology，Hospital Affiliated to Guilin Medical College，Guilin 541004,China
【Abstract】 Objective To explore the effects of blood glucose fluctuation and calcitonin gene-related peptide(CGRP) on kidney diseases in diabetic rats.Methods 40 Sprague-Dawley(SD) rats were randomly divided into control group(group A),normal blood glucose fluctuation group(group B),stable high blood glucose group(group C) and fluctuant blood glucose group(group D).Diabetes rats in group C and group D were induced by intraperitoneal injection of STZ by 60 mg/kg.Group D was given abdominal subcutaneous injection of insulin by 1-2 U at 8:30 and 14:30,while group B and group D was given intragastric administration of glucose by 2 g/kg at 8：00 and 14：00,2.0 ml once for the blood glucose fluctuation model.Nine weeks later,weight,kidney index(KI),mean blood glucose(MBG),standard deviation of blood glucose(SDBG),largest amplitude of glycemic excursions(LAGE),24 h urinary albumin,blood urea nitrogen(BUN),serum creatinine(Cr),HbA1c,blood CGRP were determined and the change of kidney microstructure was observed by microscope.Results Compared with group A and group B,the KI,MBG,SDBG,LAGE,24 h urinary albumin,BUN,Cr and HbA1c were increased,while the weight and CGRP were decreased in group C and group D(P＜0.05).Compared with group C,the KI,SDBG,LAGE,24 h urinary albumin,BUN and Cr were increased,and MBG and CGRP were decreased in group D(P＜0.05).Pearson correlation analysis showed that SDBG was positively correlated with 24 h urinary albumin(r=0.927,P＜0.01),BUN(r=0.883,P＜0.01) and Cr(r=0.825,P＜0.01),but was negatively correlated with CGRP(r=-0.823,P＜0.01).CGRP was negatively correlated with 24 h urinary albumin(r=-0.878,P＜0.01),BUN(r=-0.792,P＜0.01) and Cr(r=-0.796,P＜0.01).Conclusion Blood glucose fluctuation and the decrease of the levels of CGRP are associated with the development of diabetic nephropathy.
【Key words】 Bloo