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January 2014, Volume 17, No.3 Abstracts

Research Progress of Relationship between Physical Function and Cognitive Function in Elderly

LIU Meng-jiao,ZENG Hui,WANG Xiao-song,et al.School of Nursing of Central South University,Changsha 410013,China

    Abstract  The aging of people is often accompanied with the decline of physical and cognitive functions.Accurate evaluation of the physical and cognitive functions in elderly and the understanding of their relationship can provide reference for delaying the decline of physical and cognitive functions.This article summarizes the relationship between aging and the decline of physical and cognitive functions,and elaborates their mutual effect in order to provide evidence for the study of the relationship between physical and cognitive functions.

    Key words  AgedSomatoform disordersCognition disorders

 

Research Progress of the Correlation between Vitamin D and Liver Diseases

LIU Qi-lin,XIN Gui-jie,SHA Xiu-juan,et al.Department of Hepatology,the First Hospital of Jilin University,Changchun 130021,China

    Abstract  Scientific researches on biological characteristics and functions of vitamin D have been greatly developed in recent 30 years,vitamin D mainly participate in blood calcium regulation and maintain bone homeostasis.In recent years,there is increasing recognition that vitamin D also regulates cell proliferation and differentiation,and can optimize immune response,has anti-inflammatory and anti-fibrosis effects.Research shows that physiological functions of vitamin D are related to the pathogenesis and treatment of chronic liver diseases.This article reviews correlation between vitamin D andautoimmune liver disease,nonalcoholic fatty liver disease,chronic hepatitis B,chronic hepatitis C,alcoholic liver disease,hepatic malignant tumors and other liver diseases.

    Key words  Vitamin DLiver diseasesReview

 

 

Research Progress of Circulating MicroRNAs and Breast Cancer

LI Ya-nanXING Han-yingHAO Yu-bin.Graduate SchoolHebei Medical UniversityShijiazhuang 050017China

    Abstract  MicroRNAs(miRNAs) are a major class of small endogenous noncoding single-stranded RNA moleculeswhich participate many biological processessuch as cell proliferationdifferentiation and apoptosis.Recent studies indicate that miRNAs can be released from cells into extracellular fluidsuch as serumplasmatissue fluid and body fluidsthus circulating miRNAs are formed.The expression profiles of circulating miRNAs change under the condition of diseases like breast cancer.Circulating miRNAs are new noninvasive tumor biomarkers due to good stability and disease associationand it has become a research hot spot in the tumor diagnosistreatment and prevention.The research progress of circulating miRNAs and breast cancer is reviewed in this paper.

    Key words  Breast neoplasmsTumor markersbiologicalMicroRNAs

 

Analysis of Current Status and Influencing Factors Associated with the Family Burden of Senile Dementia

DING YanLIU JieTANG Feng-pinget al.Hunan Traditional Chinese Medical CollegeZhuzhou 412012China

    Abstract  Objective  To study the current status and influencing factors associated with the family burden of senile dementia.Methods  Using purposive sampling,a total of 190 caregivers of dementia patients were selected as study subjects from January 2011 to March 2012the patients were admitted to hospitals or at home in Changsha city.Survey was conducted using a self-designed general information questionnaire and Family Burden Scale(FBS) of patientand total FBS scores were calculated.Multiple linear regression analysis was used to explore the influencing factors associated with the family burden of senile dementia.Results  Family burden of different levels existed in 185(97.4%) caregivers of dementia patientsFBS total score of the caregivers was26.7±9.8.Multivariate analysis revealed that the influencing factors associated with total FBS score wereseverity of dementiabehavioral and psychological symptoms of dementia(BPSD)age and pension of the patientshealth conditionoccupationand caregiving hours per day of caregivers(P0.05).Conclusion  The family burden due to senile dementia is heavy and common.Heavy family burden is associated with more serious dementiahaving PBSDyounger ageand less pension of patientspoor health of caregiveroccupation of caregiver is workerand more caregiving hours.

    Key words  DementiaAgedCaregiverFamily burdenInfluencing factors

 

Memory and Behavior Problems of Patients with Dementia and Attitude of Their Caregivers

WANG Qing-yanJIANG FenCHEN San-meiet al.Nursing College of Central South UniversityChangsha 410013China

    Abstract  Objective  To investigate the occurrence situation of memory and behavior problems in patients with dementia and relative attitude of their caregiversand to provide reference evidence to further intervention for patients with different memory and behavior problems and their caregivers.Methods  A total of 153 pairs of dementia patients and their primary caregivers were selected as study subjectsthe patients were diagnosed in 9 first class tertiary hospitals in Hunan Province from April 2011 to March 2012.The memory and behavior problems of patients and the attitude of their caregivers were evaluated by RMBPCthe RMBPC was completed by caregivers.Thenprevalences of different memory and behavior problems of dementia patients were comparedand different attitudes of their caregivers were also compared.Results  In three dimensions of RMBPCmemory-related problems were found among 152(99.3%) casesdepression symptoms were found among 137(89.5%) casesand disruptive behaviors were found among 136(88.9%) casesprevalence of memory-related problems was significantly higher than those of disruptive behaviors and depression symptoms(P0.01).The distress intensity of caregivers when disruptive behaviors happened(1.95±1.13) was significantly higher than those when memory-related problems or depression symptoms happened(0.91±0.76) and (0.89±0.85)respectively(P0.01).The correlation between  number of patients with memory and behavior problems and distress intensity of their caregivers was analyzed by curve fittingand there existed a curve between themR2(0.278) value of cubic equation curve was the biggestF=229.212P0.05.Conclusion  Almost all patients with senile dementia have memory-related problemsmost patients have depression symptom and disruptive behaviordisruptive behavior is the main problem which disturb caregiversthe group is worthy of special attention.

    Key words  DementiaAgedMemory disordersConduct disorderCost of illnessCaregiversAttitude

 

Survey on Awareness State of Dementia Security in Family Caregivers of Elderly Dementia in Emergency Department

WANG De-xiu.The Second Affiliated Hospital of University of South ChinaHengyang 421001China

    Abstract  Objective  To analyze the awareness state of dementia security in family caregivers of elderly dementia in Emergency Department in order to propose solutions.Methods  84 dementia elderly admitted to the Emergency Department in our hospital from January 2011 to June 2013 and their family caregivers were selected.The reasons for the visit were analyzed and self-made questionnaires were used to survey the awareness state of dementia security of the family caregivers.Results  The reasons for visit among the 84 patientsfalling down or falling out of bed(22 cases26.2%)aspiration or ingestion(14 cases16.7%)self-injury or suicide(9 cases10.7%)burns(4 cases4.8%) and other diseases(35 cases41.6%).As concerns the family caregiversthe awareness rate was high on items placement at homewith a correct answer rate of 97.6%(82/84) and 94.0%(79/84) for item 1 and item 2〕,disease observationwith a correct answer rate of 90.5%(76/84) for item 11 and physical constraintwith a correct answer rate of 89.3%(75/84) for item 15.But the awareness rate was low on going outwith a correct answer rate of 27.4%(23/84) for item 3〕,water temperaturewith a correct answer rate of 23.8%(20/84) for item 7 and pain feeling of dementia patientswith a correct answer rate of 21.4%(18/84) for item 9.The correct answer rate for item 12 was only 11.9%(10/84).The security awareness scores of "university and above" educated family caregivers were the highestand the scores of "high school and college" educated caregivers were higher than "primary school or below" educated caregiversand the scores of college educated caregivers were also higher than junior middle school educated caregivers(P0.05).Family caregivers who have taken care of the dementia patients for more than ten years had the highest security awareness scoreswhile caregivers who have taken care of the dementia patients for less than one year had the lowest.Caregivers who had taken care of the patients one to five years had higher scores than those who less than one year and those who five to ten years(P0.05).Conclusion  The dementia security awareness state of dementia family caregivers is still low.Education on elderly dementia knowledge and high-risk behavior knowledge should be carried out.Education background and the attending time are related to the security awareness.

    Key words  DementiaAgedFamilyCaregiversSafetyCognition

 

Analysis on Abuse of Elderly Patients with Dementia by Their Caregivers-Based on the Theory of Planned Behavior

XIAO LinSUN MeiLIN Xiao-linget al.Nursing School of Central South UniversityChangsha 410013China

    Abstract  The theory of planned behavior is one of the famous attitude-behavior relationship theory in social psychologyand in foreign countries it has been widely applied in various areas of behavior researchand has been shown to significantly improve the explanatory and predictive power of behavior.This paper is based on the theorythe current situation of the elderly patients with dementia being abused by caregivers was analyzedin order to find the internal and external factors influencing the abusive behaviorsand make some countermeasures.

    Key words  DementiaAgedFamilyTortureTheory of planned behavior

 

Factors Influencing Postoperative Long-term Life Quality of the Patients Suffering from Primary Chronic Venous Insufficiency

DAI Xue-naZHOU Tao.Department of Peripheral Vascularthe First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000China

    Abstract  Objective  To discuss the factors influencing postoperative long-term life quality of the patients suffering from primary chronic venous insufficiency(PCVI).Methods  Stratified cluster sampling was used with surgical method as the stratification standard to select 160 PCVI patients admitted to our hospital from January 2006 to January 2008.The patients were divided into four groupsgroup A was the patients who had ligation and stripping of the great saphenous veinGroup B was the patients who had encircling constriction on the valve of superficial femoral vein plus ligation and stripping of the great saphenous veinGroup C was the patients who had encircling constriction on the valve of femoropoplitea plus ligation and stripping of the great saphenous veinGroup D was the patients who had encircling constriction on the valve of popliteal vein plus ligation and stripping of the great saphenous vein.Chronic venous insufficiency questionnaireCVIQ was used to assess and compare the life quality of the four groups in terms of lower limb painphysicalsocial and mental activities.The recurrence rate and incidence of complication were also compared in the four groups.Binary Logistic regression was used to analyze patients long-term life quality and influencing factors.Results  The PCVI patients were followed up for(69.2±7.2) monthsand the results showed that the lower limb painphysicalsocial(except group C) and mental activities all achieved satisfactory standard.The long-term life qualityrecurrence rate and incidence of complication showed no statistically significant difference in the four groups(P0.05).Logistic regression analysis showed that the number of combined diseases(except no regression relation with lower limb pain score)recurrence rate and incidence of complication showed regression relationship with the four aspects of life quality(P0.05).Occupation had relationship with lower limb pain score and comprehensive scoreP0.05);Age and BMI had relationship with physical and social activities scoresP0.05);Sex had relationship with mental activity score(P0.05).Conclusion  There is no difference within different surgical methods on patients life quality.The long-term life quality is affected by the number of combined diseasesrecurrence ratpostoperative complicationsoccupationageBMI and gender.Thereforereducing the incidence of postoperative recurrence and complications is a key to improve the long-term life quality.

    Key words  Vascular surgical proceduresLower extremityVenous insufficiencyQuality of life

 

Correlation between the Level of NT-proBNP before CAG and the Occurrence of Contrast-induced Nephropathy

LI Ming-zhuZHANG Jin-yingSHEN De-liang.Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

    Abstract  Objective  To investigate the correlation between the level of NT-proBNP before coronary angiography (CAG) and the occurrence of contrast-induced nephropathy(CIN) and its clinical predictive value to CIN.Methods  Data of 250 patients underwent CAG and admitted to the Department of Cardiology of the First Affiliated Hospital of Zhengzhou University from August 2012 to January 2013 were recorded.NT-proBNP,serum creatinine (Scr),blood urea nitrogen (BUN) and uric acid (UA) were detected 12 h before CAG.Scr,BUN and UA were detected again one,two,three,four and five days after CAG respectively,and simplified MDRD formula was used to estimate the eGFR.All the patients were divided into CIN group (36 cases) and non-CIN group (214 cases) 48 h within CAG.Results  The gender composition,age,incidence of hyperlipidemia,mean arterial pressure (MAP),cardiac ejection fraction (EF) and preoperative 12 h infusion volume showed no statistically significant difference between two groups(P0.05).The incidence of diabetes,postoperative 48 h infusion volume,dosage of contrast agent,PCI and coronary artery stenosis50% were significantly higher in CIN group than non-CIN group (P0.05).In CIN group,the NT-proBNP before CAG was positively correlated with the rise of Scr (r=0.786,P0.05),but negatively correlated with eGFR after CAG (r=-0.368,P=0.027).In non-CIN group,the NT-proBNP before CAG was positively correlated with Scr after CAGr=0.307P0.05,but negatively correlated with eGFR before and after CAG (r=-0.138P=0.044r=-0.203,P=0.003),but showed no correlation with the rise of Scr.When predicting the prevalence of CIN through the increase in NT-proBNP by 150 ng/L,the sensitivity was 86.1%,specificity was 59.3%,positive predictive value was 26.3% and negative predictive value was 96.2%.When predicting the prevalence of CIN through the increase in NT-proBNP by 400 ng/L,the sensitivity was 47.2%,specificity was 68.7%,positive predictive value was 20.2% and negative predictive value was 88.6%.Conclusion  Detecting the level of NT-proBNP before CAG is of good value in predicting the prevalence of CIN.NT-proBNP is related to the rise degree of Scr in CIN.

    Key words  Coronary angiographyN-terminal pro-B-type natriuretic peptideContrast media;Nephrosis

 

Relationship between Expression of p53 and the Responses to Concurrent Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer

WANG Hong-binYANG Jun-quan.Department of Radio-chemotherapy OncologyTangshan Peoples HospitalTangshan 063001China

    Abstract  Objective  To investigate the relationship between expression of p53 and the response rate to concurrent chemoradiotherapy for locally advanced non-small cell lung cancer(LA-NSCLC).Methods  86 patients with unresectable LA-NSCLC(A/B) admitted to Tangshan Peoples Hospital from July 2007 to July 2010 were selected.The expression of p53 in tumor samples was detected by the immunohistochemical method.The relationship between the expression of p53 and the responses to concurrent chemoradiotherapy were analyzed.Results  The positive expression rate of p53 was 48.8%(42/86)and it showed no correlation with sexageclinical classificationpathological typeand ECOG ZPS score(P0.05).After treatment30 patients achieved complete response(CR)27 partial response(PR)26 stable disease(SD) and 3 progression disease(PD).The objective response rate(ORR) was 66.3%(57/86)and the disease control rate(DCR) was 96.5%(83/86).Patients with positive p53 had lower ORR compared with those of negative54.8%(23/42) vs.77.3%(34/44)P0.05〕,but showed no statistically significant difference in DCR95.2%(40/42) vs.97.7%(43/44)P0.05.The median overall survival(OS) in all 86 patients was 16 monthsand the OS for the p53 positive patients was 15 months and for the p53 negative patients was 19 months.The 1-year2-year3-year OS rate of all patients was 79.1%(68/86)39.5%(34/86) and 26.7%(23/86) respectively.The 1-year2-year3-year OS rate for p53 positive patients was 73.8%(31/42)35.7%(15/42) and 21.4%(9/42)and for p53 negative patients was 84.1%(37/44)43.2%(19/44) and 31.8%(14/44).Kaplan-Meier survival analysis showed that p53 negative patients had higher survival rate compared with p53 positive patients(χ2=4.146P=0.042).Median progression-free survival(PFS) in all 86 patients was 13 monthswith p53 positive patients 12 months and p53 negative patients 15 months.The 1-year2-year3-year PFS rate of p53 positive patients was 54.8%(23/42)28.6%(12/42) and 19.0%(8/42) respectivelyand for p53 negative patients was 68.2%(30/44)40.9%(18/44) and 31.8%(14/44).Kaplan-Meier survival analysis showed that p53 negative patients had higher PFS compared with p53 positive patients(χ2=4.293P=0.038).Conclusion  p53 positive staining LA-NSCLC is correlated with unfavorable prognosis and poor response to concurrent radiochemotherapy.


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