January 2014, Volume 17, No.3 Abstracts
Research Progress of Relationship between Physical Function and Cognitive Function in Elderly
LIU Meng-jiao,ZENG Hui,WANG Xiao-song,et al.School of Nursing of Central South University,Changsha 410013,China
【Abstract】 The aging of people is often accompanied with the decline of physical and cognitive functions.Accurate evaluation of the physical and cognitive functions in elderly and the understanding of their relationship can provide reference for delaying the decline of physical and cognitive functions.This article summarizes the relationship between aging and the decline of physical and cognitive functions,and elaborates their mutual effect in order to provide evidence for the study of the relationship between physical and cognitive functions.
【Key words】 Aged；Somatoform disorders；Cognition disorders
Research Progress of the Correlation between Vitamin D and Liver Diseases
LIU Qi-lin,XIN Gui-jie,SHA Xiu-juan,et al.Department of Hepatology,the First Hospital of Jilin University,Changchun 130021,China
【Abstract】 Scientific researches on biological characteristics and functions of vitamin D have been greatly developed in recent 30 years,vitamin D mainly participate in blood calcium regulation and maintain bone homeostasis.In recent years,there is increasing recognition that vitamin D also regulates cell proliferation and differentiation,and can optimize immune response,has anti-inflammatory and anti-fibrosis effects.Research shows that physiological functions of vitamin D are related to the pathogenesis and treatment of chronic liver diseases.This article reviews correlation between vitamin D andautoimmune liver disease,nonalcoholic fatty liver disease,chronic hepatitis B,chronic hepatitis C,alcoholic liver disease,hepatic malignant tumors and other liver diseases.
【Key words】 Vitamin D；Liver diseases；Review
Research Progress of Circulating MicroRNAs and Breast Cancer
LI Ya-nan，XING Han-ying，HAO Yu-bin.Graduate School，Hebei Medical University，Shijiazhuang 050017，China
【Abstract】 MicroRNAs(miRNAs) are a major class of small endogenous noncoding single-stranded RNA molecules，which participate many biological processes，such as cell proliferation，differentiation and apoptosis.Recent studies indicate that miRNAs can be released from cells into extracellular fluid，such as serum，plasma，tissue fluid and body fluids，thus circulating miRNAs are formed.The expression profiles of circulating miRNAs change under the condition of diseases like breast cancer.Circulating miRNAs are new noninvasive tumor biomarkers due to good stability and disease association，and it has become a research hot spot in the tumor diagnosis，treatment and prevention.The research progress of circulating miRNAs and breast cancer is reviewed in this paper.
【Key words】 Breast neoplasms；Tumor markers，biological；MicroRNAs
Analysis of Current Status and Influencing Factors Associated with the Family Burden of Senile Dementia
DING Yan，LIU Jie，TANG Feng-ping，et al.Hunan Traditional Chinese Medical College，Zhuzhou 412012，China
【Abstract】 Objective To study the current status and influencing factors associated with the family burden of senile dementia.Methods Using purposive sampling,a total of 190 caregivers of dementia patients were selected as study subjects from January 2011 to March 2012，the patients were admitted to hospitals or at home in Changsha city.Survey was conducted using a self-designed general information questionnaire and Family Burden Scale(FBS) of patient，and total FBS scores were calculated.Multiple linear regression analysis was used to explore the influencing factors associated with the family burden of senile dementia.Results Family burden of different levels existed in 185(97.4%) caregivers of dementia patients，FBS total score of the caregivers was（26.7±9.8）.Multivariate analysis revealed that the influencing factors associated with total FBS score were：severity of dementia，behavioral and psychological symptoms of dementia(BPSD)，age and pension of the patients，health condition，occupation，and caregiving hours per day of caregivers(P＜0.05).Conclusion The family burden due to senile dementia is heavy and common.Heavy family burden is associated with more serious dementia，having PBSD，younger age，and less pension of patients，poor health of caregiver，occupation of caregiver is worker，and more caregiving hours.
【Key words】 Dementia；Aged；Caregiver；Family burden；Influencing factors
Memory and Behavior Problems of Patients with Dementia and Attitude of Their Caregivers
WANG Qing-yan，JIANG Fen，CHEN San-mei，et al.Nursing College of Central South University，Changsha 410013，China
【Abstract】 Objective To investigate the occurrence situation of memory and behavior problems in patients with dementia and relative attitude of their caregivers，and to provide reference evidence to further intervention for patients with different memory and behavior problems and their caregivers.Methods A total of 153 pairs of dementia patients and their primary caregivers were selected as study subjects，the patients were diagnosed in 9 first class tertiary hospitals in Hunan Province from April 2011 to March 2012.The memory and behavior problems of patients and the attitude of their caregivers were evaluated by RMBPC，the RMBPC was completed by caregivers.Then，prevalences of different memory and behavior problems of dementia patients were compared，and different attitudes of their caregivers were also compared.Results In three dimensions of RMBPC，memory-related problems were found among 152(99.3%) cases，depression symptoms were found among 137(89.5%) cases，and disruptive behaviors were found among 136(88.9%) cases，prevalence of memory-related problems was significantly higher than those of disruptive behaviors and depression symptoms(P＜0.01).The distress intensity of caregivers when disruptive behaviors happened(1.95±1.13) was significantly higher than those when memory-related problems or depression symptoms happened〔(0.91±0.76) and (0.89±0.85)，respectively〕(P＜0.01).The correlation between number of patients with memory and behavior problems and distress intensity of their caregivers was analyzed by curve fitting，and there existed a curve between them〔R2(0.278) value of cubic equation curve was the biggest，F=229.212，P＜0.05〕.Conclusion Almost all patients with senile dementia have memory-related problems，most patients have depression symptom and disruptive behavior，disruptive behavior is the main problem which disturb caregivers，the group is worthy of special attention.
【Key words】 Dementia；Aged；Memory disorders；Conduct disorder；Cost of illness；Caregivers；Attitude
Survey on Awareness State of Dementia Security in Family Caregivers of Elderly Dementia in Emergency Department
WANG De-xiu.The Second Affiliated Hospital of University of South China，Hengyang 421001，China
【Abstract】 Objective To analyze the awareness state of dementia security in family caregivers of elderly dementia in Emergency Department in order to propose solutions.Methods 84 dementia elderly admitted to the Emergency Department in our hospital from January 2011 to June 2013 and their family caregivers were selected.The reasons for the visit were analyzed and self-made questionnaires were used to survey the awareness state of dementia security of the family caregivers.Results The reasons for visit among the 84 patients：falling down or falling out of bed(22 cases，26.2%)，aspiration or ingestion(14 cases，16.7%)，self-injury or suicide(9 cases，10.7%)，burns(4 cases，4.8%) and other diseases(35 cases，41.6%).As concerns the family caregivers，the awareness rate was high on items placement at home〔with a correct answer rate of 97.6%(82/84) and 94.0%(79/84) for item 1 and item 2〕，disease observation〔with a correct answer rate of 90.5%(76/84) for item 11〕 and physical constraint〔with a correct answer rate of 89.3%(75/84) for item 15〕.But the awareness rate was low on going out〔with a correct answer rate of 27.4%(23/84) for item 3〕，water temperature〔with a correct answer rate of 23.8%(20/84) for item 7〕 and pain feeling of dementia patients〔with a correct answer rate of 21.4%(18/84) for item 9〕.The correct answer rate for item 12 was only 11.9%(10/84).The security awareness scores of "university and above" educated family caregivers were the highest，and the scores of "high school and college" educated caregivers were higher than "primary school or below" educated caregivers，and the scores of college educated caregivers were also higher than junior middle school educated caregivers(P＜0.05).Family caregivers who have taken care of the dementia patients for more than ten years had the highest security awareness scores，while caregivers who have taken care of the dementia patients for less than one year had the lowest.Caregivers who had taken care of the patients one to five years had higher scores than those who less than one year and those who five to ten years(P＜0.05).Conclusion The dementia security awareness state of dementia family caregivers is still low.Education on elderly dementia knowledge and high-risk behavior knowledge should be carried out.Education background and the attending time are related to the security awareness.
【Key words】 Dementia；Aged；Family；Caregivers；Safety；Cognition
Analysis on Abuse of Elderly Patients with Dementia by Their Caregivers-Based on the Theory of Planned Behavior
XIAO Lin，SUN Mei，LIN Xiao-ling，et al.Nursing School of Central South University，Changsha 410013，China
【Abstract】 The theory of planned behavior is one of the famous attitude-behavior relationship theory in social psychology，and in foreign countries it has been widely applied in various areas of behavior research，and has been shown to significantly improve the explanatory and predictive power of behavior.This paper is based on the theory，the current situation of the elderly patients with dementia being abused by caregivers was analyzed，in order to find the internal and external factors influencing the abusive behaviors，and make some countermeasures.
【Key words】 Dementia；Aged；Family；Torture；Theory of planned behavior
Factors Influencing Postoperative Long-term Life Quality of the Patients Suffering from Primary Chronic Venous Insufficiency
DAI Xue-na，ZHOU Tao.Department of Peripheral Vascular，the First Affiliated Hospital of Henan University of Traditional Chinese Medicine，Zhengzhou 450000，China
【Abstract】 Objective To discuss the factors influencing postoperative long-term life quality of the patients suffering from primary chronic venous insufficiency(PCVI).Methods Stratified cluster sampling was used with surgical method as the stratification standard to select 160 PCVI patients admitted to our hospital from January 2006 to January 2008.The patients were divided into four groups：group A was the patients who had ligation and stripping of the great saphenous vein；Group B was the patients who had encircling constriction on the valve of superficial femoral vein plus ligation and stripping of the great saphenous vein；Group C was the patients who had encircling constriction on the valve of femoropoplitea plus ligation and stripping of the great saphenous vein；Group D was the patients who had encircling constriction on the valve of popliteal vein plus ligation and stripping of the great saphenous vein.Chronic venous insufficiency questionnaire（CVIQ） was used to assess and compare the life quality of the four groups in terms of lower limb pain，physical，social and mental activities.The recurrence rate and incidence of complication were also compared in the four groups.Binary Logistic regression was used to analyze patients′ long-term life quality and influencing factors.Results The PCVI patients were followed up for(69.2±7.2) months，and the results showed that the lower limb pain，physical，social(except group C) and mental activities all achieved satisfactory standard.The long-term life quality，recurrence rate and incidence of complication showed no statistically significant difference in the four groups(P＞0.05).Logistic regression analysis showed that the number of combined diseases(except no regression relation with lower limb pain score)，recurrence rate and incidence of complication showed regression relationship with the four aspects of life quality(P＜0.05).Occupation had relationship with lower limb pain score and comprehensive score（P＜0.05）；Age and BMI had relationship with physical and social activities scores（P＜0.05）；Sex had relationship with mental activity score(P＜0.05).Conclusion There is no difference within different surgical methods on patients′ life quality.The long-term life quality is affected by the number of combined diseases，recurrence rat，postoperative complications，occupation，age，BMI and gender.Therefore，reducing the incidence of postoperative recurrence and complications is a key to improve the long-term life quality.
【Key words】 Vascular surgical procedures；Lower extremity；Venous insufficiency；Quality of life
Correlation between the Level of NT-proBNP before CAG and the Occurrence of Contrast-induced Nephropathy
LI Ming-zhu，ZHANG Jin-ying，SHEN De-liang.Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
【Abstract】 Objective To investigate the correlation between the level of NT-proBNP before coronary angiography (CAG) and the occurrence of contrast-induced nephropathy(CIN) and its clinical predictive value to CIN.Methods Data of 250 patients underwent CAG and admitted to the Department of Cardiology of the First Affiliated Hospital of Zhengzhou University from August 2012 to January 2013 were recorded.NT-proBNP,serum creatinine (Scr),blood urea nitrogen (BUN) and uric acid (UA) were detected 12 h before CAG.Scr,BUN and UA were detected again one,two,three,four and five days after CAG respectively,and simplified MDRD formula was used to estimate the eGFR.All the patients were divided into CIN group (36 cases) and non-CIN group (214 cases) 48 h within CAG.Results The gender composition,age,incidence of hyperlipidemia,mean arterial pressure (MAP),cardiac ejection fraction (EF) and preoperative 12 h infusion volume showed no statistically significant difference between two groups(P＞0.05).The incidence of diabetes,postoperative 48 h infusion volume,dosage of contrast agent,PCI and coronary artery stenosis＞50% were significantly higher in CIN group than non-CIN group (P＜0.05).In CIN group,the NT-proBNP before CAG was positively correlated with the rise of Scr (r=0.786,P＜0.05),but negatively correlated with eGFR after CAG (r=-0.368,P=0.027).In non-CIN group,the NT-proBNP before CAG was positively correlated with Scr after CAG（r=0.307，P＜0.05）,but negatively correlated with eGFR before and after CAG (r=-0.138，P=0.044；r=-0.203,P=0.003),but showed no correlation with the rise of Scr.When predicting the prevalence of CIN through the increase in NT-proBNP by 150 ng/L,the sensitivity was 86.1%,specificity was 59.3%,positive predictive value was 26.3% and negative predictive value was 96.2%.When predicting the prevalence of CIN through the increase in NT-proBNP by 400 ng/L,the sensitivity was 47.2%,specificity was 68.7%,positive predictive value was 20.2% and negative predictive value was 88.6%.Conclusion Detecting the level of NT-proBNP before CAG is of good value in predicting the prevalence of CIN.NT-proBNP is related to the rise degree of Scr in CIN.
【Key words】 Coronary angiography；N-terminal pro-B-type natriuretic peptide；Contrast media;Nephrosis
Relationship between Expression of p53 and the Responses to Concurrent Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer
WANG Hong-bin，YANG Jun-quan.Department of Radio-chemotherapy Oncology，Tangshan People′s Hospital，Tangshan 063001，China
【Abstract】 Objective To investigate the relationship between expression of p53 and the response rate to concurrent chemoradiotherapy for locally advanced non-small cell lung cancer(LA-NSCLC).Methods 86 patients with unresectable LA-NSCLC(ⅢA/ⅢB) admitted to Tangshan People′s Hospital from July 2007 to July 2010 were selected.The expression of p53 in tumor samples was detected by the immunohistochemical method.The relationship between the expression of p53 and the responses to concurrent chemoradiotherapy were analyzed.Results The positive expression rate of p53 was 48.8%(42/86)，and it showed no correlation with sex，age，clinical classification，pathological type，and ECOG ZPS score(P＞0.05).After treatment，30 patients achieved complete response(CR)，27 partial response(PR)，26 stable disease(SD) and 3 progression disease(PD).The objective response rate(ORR) was 66.3%(57/86)，and the disease control rate(DCR) was 96.5%(83/86).Patients with positive p53 had lower ORR compared with those of negative〔54.8%(23/42) vs.77.3%(34/44)，P＜0.05〕，but showed no statistically significant difference in DCR〔95.2%(40/42) vs.97.7%(43/44)，P＞0.05〕.The median overall survival(OS) in all 86 patients was 16 months，and the OS for the p53 positive patients was 15 months and for the p53 negative patients was 19 months.The 1-year，2-year，3-year OS rate of all patients was 79.1%(68/86)，39.5%(34/86) and 26.7%(23/86) respectively.The 1-year，2-year，3-year OS rate for p53 positive patients was 73.8%(31/42)，35.7%(15/42) and 21.4%(9/42)，and for p53 negative patients was 84.1%(37/44)，43.2%(19/44) and 31.8%(14/44).Kaplan-Meier survival analysis showed that p53 negative patients had higher survival rate compared with p53 positive patients(χ2=4.146，P=0.042).Median progression-free survival(PFS) in all 86 patients was 13 months，with p53 positive patients 12 months and p53 negative patients 15 months.The 1-year，2-year，3-year PFS rate of p53 positive patients was 54.8%(23/42)，28.6%(12/42) and 19.0%(8/42) respectively，and for p53 negative patients was 68.2%(30/44)，40.9%(18/44) and 31.8%(14/44).Kaplan-Meier survival analysis showed that p53 negative patients had higher PFS compared with p53 positive patients(χ2=4.293，P=0.038).Conclusion p53 positive staining LA-NSCLC is correlated with unfavorable prognosis and poor response to concurrent radiochemotherapy.